Actr3

Enables ATPase binding activity and actin binding activity. Involved in several processes, including positive regulation of nervous system development; positive regulation of protein localization to membrane; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including actin cytoskeleton; apical ectoplasmic specialization; and basal ectoplasmic specialization. Part of apical tubulobulbar complex. Is active in glutamatergic synapse and postsynapse. Used to study focal segmental glomerulosclerosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. Human ortholog(s) of this gene implicated in opisthorchiasis. Orthologous to human ACTR3 (actin related protein 3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Actr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Actr3 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Actr3 gene, providing context for its role in the cell.