Adam7 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including epididymis development; positive regulation of flagellated sperm motility; and positive regulation of sperm capacitation. Located in apical part of cell. Orthologous to human ADAM7 (ADAM metallopeptidase domain 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam7 |
| Official Name | ADAM metallopeptidase domain 7 [Source:RGD Symbol;Acc:62032] |
| Ensembl ID | ENSRNOG00000014054 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 7 |
| Synonyms | 9230104J12RIK, ADAM, ADAM metallopeptidase domain 7, a disintegrin and metallopeptidase domain 7, EAP, EAP1, EAP I, GP-83 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reprolysin family propeptide
- ZnMc
- endopeptidase
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- peptidase
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- protein binding
Pathways
Biological processes and signaling networks where the Adam7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- apical compartment
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- epithelial cell morphogenesis
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metalloendopeptidase activity