Tars2 Gene Summary [Rat]
Predicted to enable aminoacyl-tRNA deacylase activity; protein homodimerization activity; and threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21. Orthologous to human TARS2 (threonyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tars2 |
| Official Name | threonyl-tRNA synthetase 2, mitochondrial [Source:RGD Symbol;Acc:1308283] |
| Ensembl ID | ENSRNOG00000057194 |
| Bio databases IDs | |
| Aliases | threonyl-tRNA synthetase 2, mitochondrial |
| Synonyms | 2610024N01Rik, COXPD21, RGD1308283, TARSL1, threonyl-tRNA synthetase 2, mitochondrial, threonyl-tRNA synthetase 2, mitochondrial (putative), thrRS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tars2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- threonine-tRNA ligase
- tRNA synthetase class II core domain (G, H, P, S and T)
- HGTP_anticodon
- threonyl-tRNA synthetase
- TGS domain
- class_II_aaRS-like_core
- Anticodon binding domain
- Ubl1_cv_Nsp3_N-like
- protein homodimerization
- Threonyl and Alanyl tRNA synthetase second additional domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- combined oxidative phosphorylation deficiency 21
- Leigh syndrome
- systolic dysfunction
role in cell
- growth
- phosphorylation in
- survival
- morphology
- number
- G2/M phase
- respiration in
- Gap 0-Gap 1 phase
- autophagy in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tars2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial threonyl-tRNA aminoacylation
- threonyl-tRNA aminoacylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein homodimerization activity
- aminoacyl-tRNA editing activity
- threonine-tRNA ligase activity