Pc Gene Summary [Rat]
Enables biotin binding activity and pyruvate carboxylase activity. Involved in gluconeogenesis and positive regulation of phospholipid biosynthetic process. Predicted to be located in cytosol. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pc |
| Official Name | pyruvate carboxylase [Source:RGD Symbol;Acc:3262] |
| Ensembl ID | ENSRNOG00000019372 |
| Bio databases IDs | |
| Aliases | pyruvate carboxylase |
| Synonyms | PCB, Pcx, PYC, Pyruvate carboxylase, Pyruvate carboxylase homologous |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- biotin binding
- HMGL-like
- ATP binding
- Biotin carboxylase C-terminal domain
- enzyme
- protein binding
- D-ala D-ala ligase C-terminus
- identical protein binding
- Biotinyl_lipoyl_domains
- Conserved carboxylase domain
- acetyl-CoA carboxylase, biotin carboxylase subunit
- binding protein
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- Biotin carboxylase, N-terminal domain
- TIM-like beta/alpha barrel domains
- Biotin-requiring enzyme
- oxaloacetate decarboxylase alpha subunit
- pyruvate carboxylase
- PRK12999
Pathways
Biological processes and signaling networks where the Pc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pyruvate carboxylase deficiency
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- human immunodeficiency virus I infection
- insomnia
- lung squamous cell carcinoma
- squamous cell lung cancer
- bipolar disorder
- Burkitt lymphoma
- bipolar I disorder
role in cell
- proliferation
- degradation in
- expression in
- growth
- invasion by
- tumorigenicity
- gluconeogenesis in
- lipolysis in
- synthesis in
- 5-fluorouracil sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- lipid droplets
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- gluconeogenesis
- viral RNA genome packaging
- NADH metabolic process
- release of virus from host
- lipid metabolic process
- NADP metabolic process
- pyruvate metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- metal ion binding
- pyruvate carboxylase activity
- biotin binding