Ppip5k1 Gene Summary [Rat]
Enables 5-diphosphoinositol pentakisphosphate 1-kinase activity and inositol hexakisphosphate kinase activity. Predicted to be involved in inositol metabolic process and inositol phosphate biosynthetic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Orthologous to human PPIP5K1 (diphosphoinositol pentakisphosphate kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppip5k1 |
| Official Name | diphosphoinositol pentakisphosphate kinase 1 [Source:RGD Symbol;Acc:1311552] |
| Ensembl ID | ENSRNOG00000014436 |
| Bio databases IDs | |
| Aliases | diphosphoinositol pentakisphosphate kinase 1 |
| Synonyms | B430315C20Rik, diphosphoinositol pentakisphosphate kinase 1, HISPPD2A, hsVIP1, IP6K, IPS1, LOC100509540, LOC649956, mKIAA0377, RGD1311552, Similar to C.elegans gene encoded in cosmid k12d12(z49069), VIP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppip5k1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- diphosphoinositol-pentakisphosphate kinase
- phosphate group acceptor phosphotransferase
- inositol-hexakisphosphate kinase
- ATP binding
- phosphatase
- Histidine phosphatase superfamily (branch 2)
- Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
- Histidine phosphatase domain
Pathways
Biological processes and signaling networks where the Ppip5k1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppip5k1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate metabolic process
- inositol phosphate biosynthetic process
- inositol metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- inositol heptakisphosphate kinase activity
- inositol hexakisphosphate kinase activity
- diphosphoinositol-pentakisphosphate kinase activity
- inositol-1,3,4,5,6-pentakisphosphate kinase activity
- inositol hexakisphosphate 5-kinase activity
- inositol hexakisphosphate 3-kinase activity
- inositol hexakisphosphate 1-kinase activity