Nfkbib Gene Summary [Rat]
Predicted to be involved in cellular response to lipopolysaccharide. Predicted to act upstream of or within inflammatory response and regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm and nucleus. Orthologous to human NFKBIB (NFKB inhibitor beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfkbib |
| Official Name | NFKB inhibitor beta [Source:RGD Symbol;Acc:621887] |
| Ensembl ID | ENSRNOG00000020063 |
| Bio databases IDs | |
| Aliases | NFKB inhibitor beta |
| Synonyms | I-kappa-B-beta, I(Kappa)B(beta), I kappa B β, IkB, IKBB, IKB-beta, IKB-β, I-κ-B-β, I(κ)B(β), NF-kappa-BIB, NFKB inhibitor beta, NFKB inhibitor β, NF-κ-BIB, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta, nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor, β, TRIP9 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nfkbib often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEST domain
- transcription regulator
- Ankyrin repeats (many copies)
- transcription co-activator
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- phosphorylation site
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Nfkbib gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Angiopoietin Signaling
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- Hypoxia Signaling in the Cardiovascular System
- Induction of Apoptosis by HIV1
- LPS-stimulated MAPK Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Molecular Mechanisms of Cancer
- NF-κB Activation by Viruses
- NF-κB Signaling
- PEDF Signaling
- Prostate Cancer Signaling
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of IL-17A in Arthritis
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- TWEAK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- asthma
- disease-free survival
- dermatitis
- obesity
- collagen-induced arthritis
- osteolysis
- septic shock
- endotoxin shock response
- granulocytosis
role in cell
- formation
- expression in
- production in
- necrosis
- cell death
- apoptosis
- growth
- transactivation in
- survival
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- Cytoplasm
- lysosome
- cytosol
- microsome
- lysosome membrane
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nfkbib gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- cellular response to lipopolysaccharide
- transcription, DNA-dependent
- signal transduction
- positive regulation of transcription, DNA-dependent
- regulation of I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity