Slf2 Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Predicted to be located in PML body and chromatin. Predicted to be active in nucleus and site of double-strand break. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome. Orthologous to human SLF2 (SMC5-SMC6 complex localization factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slf2 |
| Official Name | SMC5-SMC6 complex localization factor 2 [Source:RGD Symbol;Acc:1560300] |
| Ensembl ID | ENSRNOG00000014482 |
| Bio databases IDs | |
| Aliases | SMC5-SMC6 complex localization factor 2 |
| Synonyms | 3632432H19, ATELS1, C10orf6, FAM178A, RGD1560300, SMC5-SMC6 complex localization factor 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- binding protein
- protein binding
- Coiled-coil and Nse Interacting (CANIN) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Atelis syndrome type 1
- organismal death
regulated by
- HuH7 cells
regulates
- protein-protein complex
- CHEK1
- CLSPN
- covalently closed circular DNA
role in cell
- cell viability
- expression in
- transcription in
- phosphorylation in
- formation
- formation in
- DNA damage response
- entrapment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- Nucleus
- nucleoplasm
- PML nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of maintenance of mitotic sister chromatid cohesion
- protein sumoylation
- double-strand break repair via homologous recombination
- response to DNA damage stimulus
- positive regulation of double-strand break repair
- positive regulation of protein complex assembly
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- site of double-strand break
- PML body
- intracellular membrane-bounded organelle
- Smc5-Smc6 complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding