SLF2 Gene Summary [Human]
Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in chromatin; nucleoplasm; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLF2 |
| Official Name | SMC5-SMC6 complex localization factor 2 [Source:HGNC Symbol;Acc:HGNC:17814] |
| Ensembl ID | ENSG00000119906 |
| Bio databases IDs | |
| Aliases | SMC5-SMC6 complex localization factor 2 |
| Synonyms | 3632432H19, ATELS1, C10orf6, FAM178A, RGD1560300, SMC5-SMC6 complex localization factor 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- binding protein
- protein binding
- Coiled-coil and Nse Interacting (CANIN) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- HuH7 cells
disease
- non-insulin-dependent diabetes mellitus
- Atelis syndrome type 1
- organismal death
role in cell
- cell viability
- expression in
- transcription in
- phosphorylation in
- formation
- formation in
- DNA damage response
- entrapment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- Nucleus
- nucleoplasm
- PML nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of maintenance of mitotic sister chromatid cohesion
- protein sumoylation
- double-strand break repair via homologous recombination
- response to DNA damage stimulus
- positive regulation of double-strand break repair
- positive regulation of protein complex assembly
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- site of double-strand break
- PML body
- intracellular membrane-bounded organelle
- Smc5-Smc6 complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding