Bdh2 Gene Summary [Rat]
Predicted to enable 3-hydroxybutyrate dehydrogenase activity; NAD binding activity; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including fatty acid beta-oxidation; heme metabolic process; and siderophore biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human BDH2 (3-hydroxybutyrate dehydrogenase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bdh2 |
| Official Name | 3-hydroxybutyrate dehydrogenase 2 [Source:RGD Symbol;Acc:1309898] |
| Ensembl ID | ENSRNOG00000014490 |
| Bio databases IDs | |
| Aliases | 3-hydroxybutyrate dehydrogenase 2 |
| Synonyms | 1810026B04Rik, 3-hydroxybutyrate dehydrogenase 2, 3-hydroxybutyrate dehydrogenase, type 2, DHRS6, EFA6R, PRO20933, SDR15C1, UCPA-OR, UNQ6308 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bdh2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- NAD or NADH binding
- CH-CH group:NAD or NADP oxidoreductase
- 3-hydroxybutyrate dehydrogenase
- 3-oxoacyl-(acyl-carrier-protein) reductase
- pteridine reductase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bdh2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- fatty acid beta-oxidation
- intracellular sequestering of iron ion
- heme metabolic process
- siderophore biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- 4-oxoproline reductase activity
- NAD binding
- oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
- 3-hydroxybutyrate dehydrogenase activity