Mad2l1 Gene Summary [Rat]
Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including establishment of centrosome localization; negative regulation of protein metabolic process; and regulation of mitotic metaphase/anaphase transition. Predicted to act upstream of or within mitotic sister chromatid segregation and negative regulation of mitotic cell cycle. Predicted to be located in several cellular components, including chromosome, centromeric region; perinuclear region of cytoplasm; and spindle. Predicted to be part of mitotic checkpoint complex; mitotic spindle assembly checkpoint MAD1-MAD2 complex; and nuclear pore nuclear basket. Predicted to be active in cytoplasm; kinetochore; and nucleoplasm. Orthologous to human MAD2L1 (mitotic arrest deficient 2 like 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mad2l1 |
| Official Name | mitotic arrest deficient 2 like 1 [Source:RGD Symbol;Acc:1310889] |
| Ensembl ID | ENSRNOG00000005376 |
| Bio databases IDs | |
| Aliases | mitotic arrest deficient 2 like 1 |
| Synonyms | CMT2, HSMAD2, MAD2, MAD2 mitotic arrest deficient-like 1, MADP2, mitotic arrest deficient 2 like 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mad2l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- ETGE motif
- protein binding
- HORMA domain
- identical protein binding
- ESGE motif
- DLG motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-squamous non-small cell lung cancer
- epithelial neoplasia
- neoplasia
- epithelial cancer
- cancer
- breast cancer
- organismal death
- idiopathic pulmonary fibrosis
- colorectal cancer
- hepatocellular carcinoma
role in cell
- survival
- apoptosis
- cell death
- cell viability
- proliferation
- quantity
- formation
- adhesion
- mitosis
- spindle checkpoint
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- chromosome
- nucleoplasm
- spindle pole
- mitotic spindle
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mad2l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- establishment of mitotic spindle orientation
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- establishment of centrosome localization
- negative regulation of apoptotic process
- mitotic sister chromatid segregation
- negative regulation of mitotic cell cycle
- negative regulation of protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- mitotic spindle
- cytoplasm
- spindle pole
- cytosol
- mitotic checkpoint complex
- kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity