Pcsk1 Gene Summary [Rat]
Enables endopeptidase activity. Involved in several processes, including nervous system development; protein processing; and response to forskolin. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and trans-Golgi network. Used to study hyperglycemia and type 2 diabetes mellitus. Biomarker of hyperglycemia; hyperthyroidism; hypothyroidism; islet cell tumor; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcsk1 |
| Official Name | proprotein convertase subtilisin/kexin type 1 [Source:RGD Symbol;Acc:3272] |
| Ensembl ID | ENSRNOG00000011107 |
| Bio databases IDs | |
| Aliases | proprotein convertase subtilisin/kexin type 1 |
| Synonyms | BDP, BMIQ12, DCE, Dyn-converting enzyme, NEC1, PC1, PC1/3, PC3, Phpp-1, proprotein convertase subtilisin/kexin type 1, SPC3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcsk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase S8 pro-domain
- Subtilase family
- peptidase
- coiled-coil domain
- Prohormone convertase enzyme
- identical protein binding
- Peptidase domain in the S8 and S53 families
- endopeptidase
- serine endopeptidase
- transmembrane domain
- Proprotein convertase P-domain
- pro domain
- G-protein binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- weight gain
- obesity
- hypogonadotropic hypogonadism
- dwarfism
- deficiency of proprotein convertase 1/3
- amenorrhea
- androgenic alopecia
- early-onset morbid obesity
role in cell
- number
- differentiation
- depletion
- accumulation
- abnormal morphology
- inactivation
- shrinkage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- Extracellular Space
- cell periphery
- perinuclear region
- granules
- cytosol
- endoplasmic reticulum lumen
- microsome
- trans Golgi network
- nerve ending
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- secretory granules
- perikaryon
- dendrites
- axon terminals
- premelanosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pcsk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin processing
- cell-cell signaling
- response to axon injury
- neurogenesis
- response to xenobiotic stimulus
- response to peptide hormone stimulus
- pituitary gland development
- response to glucose stimulus
- response to calcium ion
- proteolysis
- peptide biosynthetic process
- response to glucocorticoid stimulus
- response to interleukin-1
- response to lipopolysaccharide
- response to fatty acid
- protein autoprocessing
- positive regulation of protein secretion
- peptide hormone processing
- response to nutrient levels
- response to chlorate
- pancreas development
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- trans-Golgi network
- perinuclear region of cytoplasm
- membrane
- secretory granule lumen
- transport vesicle
- perikaryon
- neuron projection
- axon terminus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- serine-type endopeptidase activity