Cby1 Gene Summary [Rat]
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Cby1 |
| Official Name | chibby family member 1, beta catenin antagonist [Source:RGD Symbol;Acc:708481] |
| Ensembl ID | ENSRNOG00000013892 |
| Bio databases IDs | |
| Aliases | chibby family member 1, beta catenin antagonist |
| Synonyms | 1110014P06Rik, arb1, C22orf2, CBY, Chibby1, chibby 1, beta catenin antagonist, chibby 1, β catenin antagonist, chibby family member 1, beta catenin antagonist, chibby family member 1, β catenin antagonist, HS508I15A, PGEA1, PGEA14, PIGEA-14 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cby1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-catenin binding
- Cby_like
- protein homodimerization
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Joubert syndrome type 1
- laryngeal squamous cell carcinoma
- squamous cell cancer of the larynx
- anemia
- sinusitis
- hypoplasia
- otitis media
- weight gain
- infection by bacteria
role in cell
- phosphorylation in
- abnormal morphology
- differentiation
- adipogenesis
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mother centriole
- Nucleus
- basal bodies
- centrosome
- centriole
- cytoplasmic aggregates
- cytosol
- apical cell surfaces
- trans Golgi network
- nucleoplasm
- nucleoli
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cby1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- protein homotetramerization
- cilium morphogenesis
- negative regulation of transcription, DNA-dependent
- protein localization
- canonical Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- fat cell differentiation
- floor plate development
- cardiac muscle cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- trans-Golgi network
- centriole
- cilium basal body
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- beta-catenin binding