Dhx38 Gene Summary [Rat]
Predicted to enable 3'-5' RNA helicase activity and RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa 84. Orthologous to human DHX38 (DEAH-box helicase 38). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhx38 |
| Official Name | DEAH-box helicase 38 [Source:RGD Symbol;Acc:1310345] |
| Ensembl ID | ENSRNOG00000014619 |
| Bio databases IDs | |
| Aliases | DEAH-box helicase 38 |
| Synonyms | 5730550P09Rik, DDX38, DEAH-box helicase 38, KIAA0224, PRP16, PRPF16, RP84 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dhx38 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase associated domain (HA2)
- Helicase associated domain (HA2) Add an annotation
- Oligonucleotide/oligosaccharide-binding (OB)-fold
- helicase superfamily c-terminal domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- RNA helicase
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinitis pigmentosa type 84
- autosomal recessive retinitis pigmentosa
- primary genetic hyperlipidemia
- retinal dystrophy
- coronary artery disease
- angina pectoris
- retinitis pigmentosa
role in cell
- cell viability
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dhx38 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- membrane
- spliceosomal complex
- intracellular
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- RNA helicase activity
- 3'-5' RNA helicase activity