Gls Gene Summary [Rat]
Predicted to enable glutaminase activity and identical protein binding activity. Predicted to be involved in glutamine family amino acid metabolic process; intracellular glutamate homeostasis; and protein homotetramerization. Predicted to act upstream of or within chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and suckling behavior. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (glutaminase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gls |
| Official Name | glutaminase [Source:RGD Symbol;Acc:2707] |
| Ensembl ID | ENSRNOG00000056246 |
| Bio databases IDs | |
| Aliases | glutaminase |
| Synonyms | 6330442B14, AAD20, AI314027, B230365M23Rik, CASGID, DEE71, EIEE71, GAM, GDPAG, GLS1, Glut, glutaminase, Kga, RATGLUT |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gls often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glutaminase
- Ankyrin repeats (many copies)
- EF-hand domain
- Ankyrin repeats (3 copies)
- PRK00971
- enzyme
- protein binding
- identical protein binding
- Ankyrin repeat
Pathways
Biological processes and signaling networks where the Gls gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- neoplasia
- epithelial cancer
- acute myeloid leukemia
- hereditary disorder
- systemic lupus erythematosus
- lung neoplasm
- early infantile epileptic encephalopathy type 71
- infantile cataract, skin abnormalities, glutamate excess, and impaired intellectual development
- breast cancer
role in cell
- apoptosis
- proliferation
- growth
- cell death
- expression in
- production in
- quantity
- cell viability
- tumorsphere formation
- CPI-613 sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- membrane ruffles
- mitochondrial matrix
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gls gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate biosynthetic process
- protein homotetramerization
- suckling behavior
- synaptic transmission
- regulation of respiratory gaseous exchange by neurological system process
- glutamine catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
- synapse
Molecular Function
What the gene product does at the molecular level
- glutaminase activity
- protein binding