Dzip1l Gene Summary [Rat]
Predicted to enable zinc ion binding activity. Predicted to be involved in cilium assembly and regulation of protein localization. Predicted to act upstream of or within several processes, including ciliary transition zone assembly; neural tube development; and protein localization to cilium. Predicted to be located in several cellular components, including cytoskeleton; intercellular bridge; and nucleoplasm. Predicted to be active in ciliary basal body and cytoplasm. Human ortholog(s) of this gene implicated in polycystic kidney disease 5. Orthologous to human DZIP1L (DAZ interacting zinc finger protein 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dzip1l |
| Official Name | DAZ interacting zinc finger protein 1-like [Source:RGD Symbol;Acc:1311430] |
| Ensembl ID | ENSRNOG00000014746 |
| Bio databases IDs | |
| Aliases | DAZ interacting zinc finger protein 1-like |
| Synonyms | 2610524A10Rik, Actn1, Alpha actinin 1, DAZ interacting protein 1-like, DAZ interacting zinc finger protein 1-like, DZIP2, PKD5, RGD1311430, α actinin 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dzip1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- Domain of unknown function (DUF4659)
- protein binding
- Iguana/Dzip1-like DAZ-interacting protein N-terminal
- Intermediate filament protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- microtubule cytoskeleton
- cilia
- basal bodies
- centriole
- axonemes
- cytoplasmic bridges
- cytosol
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dzip1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- regulation of protein localization
- smoothened signaling pathway
- floor plate development
- neural tube patterning
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- cytoplasm
- centriole
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding