Themis Gene Summary [Rat]
Predicted to be involved in T cell receptor signaling pathway; negative T cell selection; and positive T cell selection. Predicted to be located in cell-cell junction. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm and nucleus. Used to study inflammatory bowel disease. Orthologous to human THEMIS (thymocyte selection associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Themis |
| Official Name | thymocyte selection associated [Source:RGD Symbol;Acc:1560849] |
| Ensembl ID | ENSRNOG00000014979 |
| Bio databases IDs | |
| Aliases | thymocyte selection associated |
| Synonyms | C6orf190, C6orf207, E430004N04Rik, GASP, LOC112267973, RGD1560849, SPOT, THEMIS1, thylex, thymocyte selection associated, TSEPA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Themis often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cell-cycle sustaining, positive selection,
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- colorectal cancer
- diabetic nephropathy
- uterine leiomyoma
- leiomyomatosis
- celiac disease
role in cell
- phosphorylation in
- proliferation
- number
- differentiation
- ubiquitination in
- development
- abnormal morphology
- positive selection
- negative selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- intercellular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Themis gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative T cell selection
- adaptive immune response
- positive T cell selection
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell-cell junction
- cytoplasm
- signalosome
Molecular Function
What the gene product does at the molecular level
- protein binding