THEMIS Gene Summary [Human]
This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | THEMIS |
| Official Name | thymocyte selection associated [Source:HGNC Symbol;Acc:HGNC:21569] |
| Ensembl ID | ENSG00000172673 |
| Bio databases IDs | |
| Aliases | thymocyte selection associated, thymocyte expressed molecule involved in selection |
| Synonyms | C6orf190, C6orf207, E430004N04Rik, GASP, LOC112267973, RGD1560849, SPOT, THEMIS1, thylex, thymocyte selection associated, TSEPA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THEMIS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cell-cycle sustaining, positive selection,
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- colorectal cancer
- diabetic nephropathy
- uterine leiomyoma
- leiomyomatosis
- celiac disease
role in cell
- phosphorylation in
- proliferation
- number
- differentiation
- ubiquitination in
- development
- abnormal morphology
- positive selection
- negative selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- intercellular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THEMIS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative T cell selection
- adaptive immune response
- positive T cell selection
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell-cell junction
- cytoplasm
- signalosome
Molecular Function
What the gene product does at the molecular level
- protein binding