Loxl4 Gene Summary [Rat]
Predicted to enable protein-lysine 6-oxidase activity. Predicted to be involved in collagen fibril organization. Predicted to be located in extracellular region. Predicted to be part of receptor complex. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human LOXL4 (lysyl oxidase like 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Loxl4 |
| Official Name | lysyl oxidase-like 4 [Source:RGD Symbol;Acc:1308588] |
| Ensembl ID | ENSRNOG00000015727 |
| Bio databases IDs | |
| Aliases | lysyl oxidase-like 4 |
| Synonyms | 4833426I20Rik, EER-7, LOXC, lysyl oxidase-like 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loxl4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- protein-lysine 6-oxidase
- enzyme
- protein binding
- Lysyl oxidase
- Scavenger receptor Cys-rich
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- HER2 negative hormone receptor negative breast cancer
- metabolic syndrome X
- bleomycin-induced pulmonary fibrosis
- coronary artery disease
- acute-on-chronic liver failure
- myocardial infarction
- bladder neoplasm
- bladder neoplasia
role in cell
- expression in
- colony formation
- invasion by
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loxl4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-lysine oxidation
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- receptor complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- protein-lysine 6-oxidase activity