Lox Gene Summary [Rat]
Enables copper ion binding activity and protein-lysine 6-oxidase activity. Involved in extracellular matrix organization; response to steroid hormone; and response to xenobiotic stimulus. Acts upstream of or within cell chemotaxis; platelet-derived growth factor receptor-beta signaling pathway; and protein oxidation. Located in extracellular matrix. Used to study abdominal aortic aneurysm; arteriosclerosis; coronary artery disease; coronary restenosis; and hypertension. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; colon adenocarcinoma; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lox |
| Official Name | lysyl oxidase [Source:RGD Symbol;Acc:3015] |
| Ensembl ID | ENSRNOG00000014426 |
| Bio databases IDs | |
| Aliases | lysyl oxidase |
| Synonyms | AAT10, H-rev142, LYSINE OXIDASE, lysyl oxidase, rrg, Rrg1, Similar to lox, TSC-160 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine receptor homology domain
- copper ion binding
- binding protein
- catalytic domain
- protein-lysine 6-oxidase
- collagen binding
- enzyme
- protein binding
- Lysyl oxidase
- pro domain
Pathways
Biological processes and signaling networks where the Lox gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell cancer of the oral cavity
- oral squamous cell carcinoma
- metastasis
- neoplasia
- head and neck neoplasia
- gastrointestinal neoplasia
- Duchenne muscular dystrophy
- obesity
- organismal death
- bleeding
role in cell
- apoptosis
- expression in
- activation in
- proliferation
- differentiation
- activation
- growth
- phosphorylation in
- migration
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- S-layer
- Nucleus
- cytoplasmic particles
- cytosol
- extracellular matrix
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lox gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- muscle cell homeostasis
- blood vessel morphogenesis
- response to xenobiotic stimulus
- cell chemotaxis
- heart development
- DNA biosynthetic process
- osteoblast differentiation
- peptidyl-lysine oxidation
- lung development
- bone mineralization
- platelet-derived growth factor receptor-beta signaling pathway
- muscle cell development
- regulation of megakaryocyte differentiation
- regulation of apoptotic process
- response to steroid hormone stimulus
- connective tissue development
- elastic fiber assembly
- regulation of protein phosphorylation
- ascending aorta development
- descending aorta development
- regulation of gene expression
- collagen fibril organization
- regulation of transforming growth factor beta receptor signaling pathway
- regulation of striated muscle tissue development
- negative regulation of protein kinase B signaling cascade
- regulation of platelet-derived growth factor receptor-beta signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- collagen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- collagen binding
- small molecule binding
- protein-lysine 6-oxidase activity
- binding, bridging