Mex3c Gene Summary [Rat]
This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | Mex3c |
| Official Name | mex-3 RNA binding family member C [Source:RGD Symbol;Acc:1309023] |
| Ensembl ID | ENSRNOG00000015777 |
| Bio databases IDs | |
| Aliases | mex-3 RNA binding family member C |
| Synonyms | A130001D14Rik, BM-013, IMAGE:4828930, LOC105372118, mex-3 RNA binding family member C, RKHD2, RNF194 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mex3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- K homology (KH) RNA-binding domain, type I
- KH domain
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- protein binding
- K homology RNA-binding domain
- Zinc finger, C3HC4 type (RING finger)
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- epithelial cancer
- metastasis
- atrial fibrillation
- hepatocellular carcinoma
- liver cancer
regulated by
- bone marrow-derived macrophages
- p30II
- KAT5
role in cell
- activation in
- invasion by
- ubiquitination in
- production in
- differentiation
- structural deficit
- migration
- signaling in
- degradation in
- missegregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic particles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mex3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chondrocyte hypertrophy
- energy homeostasis
- regulation of fat cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding