Dtna Gene Summary [Rat]
Enables PDZ domain binding activity and phosphatase binding activity. Predicted to be involved in synaptic signaling. Located in axon and sarcolemma. Is extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in cardiomyopathy and left ventricular noncompaction. Orthologous to human DTNA (dystrobrevin alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dtna |
| Official Name | dystrobrevin, alpha [Source:RGD Symbol;Acc:1561985] |
| Ensembl ID | ENSRNOG00000016671 |
| Bio databases IDs | |
| Aliases | dystrobrevin, alpha |
| Synonyms | 2210407P21RIK, a-DB-1, adbn, Alpha dystrobrevin 2, D18S892E, DRP3, DTN, Dtna-ps1, DYSTROBREVIN alpha, dystrobrevin, alpha, DYSTROBREVIN α, dystrobrevin, α, Gm19389, LVNC1, MMCKR2, RGD1561985, α dystrobrevin, α dystrobrevin 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dtna often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- ZZ
- B-box-type zinc finger superfamily
- EF hand
- EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
- coiled-coil domain
- protein binding
- zinc finger domain
- phosphatase binding
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- glioblastoma
- glioblastoma cancer
- primary dilated cardiomyopathy
- ventricular noncompaction
- endometrioma
- epileptic seizure
- cardiac fibrosis
- Huntington disease
- tumorigenesis
role in cell
- formation
- formation in
- expression in
- synaptic transmission
- morphology
- stabilization
- stability
- length
- abnormal morphology
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- intermediate filament cytoskeleton
- Cytoplasm
- cell periphery
- Nucleus
- cytosol
- cytoplasmic face of plasma membrane
- nucleoplasm
- neuromuscular junctions
- synapse
- sarcolemma
- cellular protrusions
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dtna gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuromuscular synaptic transmission
- signal transduction
- synaptic transmission
- striated muscle contraction
Cellular Component
Where in the cell the gene product is active
- intermediate filament cytoskeleton
- cytoplasm
- sarcolemma
- extrinsic to internal side of plasma membrane
- cell junction
- macromolecular complex
- synapse
- plasma membrane
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- PDZ domain binding