Hars2 Gene Summary [Rat]
Predicted to enable RNA binding activity; histidine-tRNA ligase activity; and identical protein binding activity. Predicted to be involved in histidyl-tRNA aminoacylation. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human HARS2 (histidyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hars2 |
| Official Name | histidyl-tRNA synthetase 2, mitochondrial [Source:RGD Symbol;Acc:1308426] |
| Ensembl ID | ENSRNOG00000016087 |
| Bio databases IDs | |
| Aliases | histidyl-tRNA synthetase 2, mitochondrial |
| Synonyms | 4631412B19Rik, DUE-B, Hars2l, HARSL, HARSR, HisRS, histidyl-tRNA synthetase 2, histidyl-tRNA synthetase 2, mitochondrial, HO3, PRLTS2, RGD1308426, Zmat2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hars2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histidine-tRNA ligase
- HGTP_anticodon
- class_II_aaRS-like_core
- Anticodon binding domain
- histidyl-tRNA synthetase
- ATP phosphoribosyltransferase, regulatory subunit
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Perrault syndrome type 2
- gonadal dysgenesis with auditory dysfunction, autosomal recessive inheritance
- gastric adenocarcinoma
- gastric epithelial cancer
- sensorineural hearing loss
regulated by
- Influenza A virus (A/Bangkok/RX73(H3N2))
regulates
- tRNA-His
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hars2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA aminoacylation for protein translation
- histidyl-tRNA aminoacylation
- translation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- histidine-tRNA ligase activity
- ATP binding
- identical protein binding
- RNA binding
- protein binding