Slc17a6 Gene Summary [Rat]
Enables chloride channel activity and secondary active transmembrane transporter activity. Involved in several processes, including hippocampus development; neurotransmitter loading into synaptic vesicle; and sodium-dependent phosphate transport. Located in cytoplasmic vesicle; excitatory synapse; and pericellular basket. Is active in synaptic vesicle membrane. Biomarker of transient cerebral ischemia. Orthologous to human SLC17A6 (solute carrier family 17 member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc17a6 |
| Official Name | solute carrier family 17 member 6 [Source:RGD Symbol;Acc:620531] |
| Ensembl ID | ENSRNOG00000016147 |
| Bio databases IDs | |
| Aliases | solute carrier family 17 member 6 |
| Synonyms | 2900073D12Rik, DNPI, GVT2, solute carrier family 17 member 6, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6, VGLUT2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc17a6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- inorganic phosphate transporter
- benzoate transport
- glutamate transporter
- chloride channel
- Major Facilitator Superfamily
- potassium:hydrogen antiporter
- Na(+)-dependent inorganic phosphate cotransporter
- sodium:phosphate symporter
- uniporter
- transporter
Pathways
Biological processes and signaling networks where the Slc17a6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- pain
- thermal hyperalgesia
- respiratory failure
- motor dysfunction or movement disorder
- weight gain
- starvation
- cyanosis
- pervasive developmental disorder
role in cell
- quantity
- survival
- neurotransmission
- synaptic transmission
- density
- abnormal morphology
- development
- accumulation in
- survival in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- membrane fraction
- synaptic vesicle membrane
- Cytoplasm
- presynaptic regions
- cellular membrane
- presynaptic membrane
- synaptic vesicles
- neurites
- nerve ending
- early endosomes
- secretory granules
- membrane processes
- perikaryon
- axons
- axon terminals
- mossy fiber boutons
- presynaptic terminals
- excitatory synapses
- clathrin-coated vesicles
- cis Golgi cisternae
- parallel fiber
- mossy fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc17a6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphate ion homeostasis
- ion transport
- potassium ion transmembrane transport
- phosphate ion transport
- L-glutamate import
- sodium-dependent phosphate transport
- regulation of synapse structure and activity
- sodium ion transmembrane transport
- L-glutamate transport
- anion transport
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- excitatory synapse
- synaptic vesicle membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sodium:phosphate symporter activity
- neurotransmitter transporter activity
- potassium:hydrogen antiporter activity
- chloride channel activity
- L-glutamate transmembrane transporter activity