Hnrnpab Gene Summary [Rat]
Enables sequence-specific double-stranded DNA binding activity. Involved in cellular response to amino acid stimulus and regulation of intracellular mRNA localization. Located in dendrite and neuronal ribonucleoprotein granule. Part of ribonucleoprotein complex. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hnrnpab |
| Official Name | heterogeneous nuclear ribonucleoprotein A/B [Source:RGD Symbol;Acc:69255] |
| Ensembl ID | ENSRNOG00000003645 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein A/B |
| Synonyms | 3010025C11RIK, A1F-C1, ABBP1, CBF-A, Cgbf, Cgbfa, DBP40, heterogeneous nuclear ribonucleoprotein A/B, HNRNP type A/B, HNRPAB, LOC100910156, LOC103689931, NUCLEAR RIBONUCLEOPROTEIN A/B, Nucleic acid binding factor prm10, ROAA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hnrnpab often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- glycine rich domain
- RNA recognition motif (RRM) superfamily
- ATP-binding domain
- CBFNT (NUC161) domain
- RNA recognition motif
- mRNA binding
- enzyme
- protein binding
- glutamine-rich domain
- glycine tyrosine rich domain
- sequence-specific DNA binding
- RNA binding
- binding protein
- double-stranded DNA binding
- RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- metastasis
- organismal death
- Alzheimer disease
- allergic pulmonary eosinophilia
role in cell
- expression in
- degradation in
- growth
- morphology
- invasion by
- transcription in
- transactivation in
- CSN5i-3 sensitivity
- alternative splicing in
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- postsynaptic region
- Mitochondria
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hnrnpab gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of gene expression
- epithelial to mesenchymal transition
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- mRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- mRNA editing complex
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding