Slc1a3 Gene Summary [Rat]
Enables high-affinity L-glutamate transmembrane transporter activity. Involved in L-aspartate import across plasma membrane; L-glutamate import across plasma membrane; and malate-aspartate shuttle. Acts upstream of or within L-glutamate transmembrane transport. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and neuronal cell body. Part of membrane protein complex. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc1a3 |
| Official Name | solute carrier family 1 member 3 [Source:RGD Symbol;Acc:3698] |
| Ensembl ID | ENSRNOG00000016163 |
| Bio databases IDs | |
| Aliases | solute carrier family 1 member 3 |
| Synonyms | AI504299, B430115D02Rik, EA6, EAAT1, GLAST, GLAST-1, GLU-T, GluT-1, Gmt1, MGluT1, solute carrier family 1 (glial high affinity glutamate transporter), member 3, solute carrier family 1 member 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc1a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium:dicarboxylate symporter family
- glutamate transporter
- glutamate:sodium symporter
- TcyP
- glutamate binding
- protein binding
- high-affinity glutamate transporter
- acidic amino acid transporter
- transporter
- amino acid binding
Pathways
Biological processes and signaling networks where the Slc1a3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- disorder of pregnancy
- cerebellar ataxia
- major depression
- schizophrenia
- polycystic kidney disease
- cervical spondylotic myelopathy
- COVID-19
- spinocerebellar ataxia type 7
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- dilated cardiomyopathy
regulates
- L-glutamic acid
- D-glucose
- GABA
- Na+
- glutathione
- 2-deoxyglucose
- K+
- neurotransmitter
- dehydroascorbic acid
- ion
role in cell
- apoptosis
- cell death
- survival
- loss
- proliferation
- number
- migration
- differentiation
- morphogenesis
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cell periphery
- perinuclear region
- microvesicles
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- apical membrane
- basolateral membrane
- basal membrane
- mitochondrial inner membrane
- dendritic spines
- neurites
- synapse
- cytoplasmic vesicles
- detergent insoluble microdomains
- cellular protrusions
- perikaryon
- exosomes
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc1a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- L-glutamate import
- positive regulation of synaptic transmission
- response to antibiotic
- response to wounding
- synaptic transmission
- cranial nerve development
- cellular sodium ion homeostasis
- cell morphogenesis involved in neuron differentiation
- response to xenobiotic stimulus
- gamma-aminobutyric acid biosynthetic process
- response to light stimulus
- sensory perception of sound
- neurotransmitter transport
- ion transport
- neurotransmitter uptake
- cellular response to cocaine
- auditory behavior
- transepithelial transport
- neutral amino acid transport
- L-glutamate transport
- D-aspartate import
- neuromuscular process controlling balance
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- perinuclear region of cytoplasm
- membrane
- cytoplasmic vesicle
- synapse
- neuronal cell body
- neuron projection
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- neutral amino acid transmembrane transporter activity
- glutamate binding
- high-affinity glutamate transmembrane transporter activity
- glutamate:sodium symporter activity
- L-glutamate transmembrane transporter activity