Edf1 Gene Summary [Rat]
This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | Edf1 |
| Official Name | endothelial differentiation-related factor 1 [Source:RGD Symbol;Acc:1308073] |
| Ensembl ID | ENSRNOG00000016272 |
| Bio databases IDs | |
| Aliases | endothelial differentiation-related factor 1 |
| Synonyms | 0610008L11Rik, CAP-19, CFAP280, endothelial differentiation-related factor 1, MBF1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Edf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcriptional regulator, y4mF family
- transcription regulator
- transcription co-activator
- binding protein
- Helix-turn-helix XRE-family like proteins
- Helix-turn-helix
- transcription factor binding
- protein binding
- HTH_XRE
- Multiprotein bridging factor 1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Edf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- endothelial cell differentiation
- regulation of transcription, DNA-dependent
- positive regulation of DNA binding
- regulation of lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- calmodulin binding
- RNA binding
- protein binding
- transcription coactivator activity
- TFIID-class transcription factor binding