Fbxo11 Gene Summary [Rat]
Predicted to enable protein-arginine N-methyltransferase activity; ubiquitin-like ligase-substrate adaptor activity; and ubiquitin-protein transferase activity. Involved in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel and positive regulation of protein catabolic process. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in breast carcinoma and lung non-small cell carcinoma. Orthologous to human FBXO11 (F-box protein 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo11 |
| Official Name | F-box protein 11 [Source:RGD Symbol;Acc:727935] |
| Ensembl ID | ENSRNOG00000016396 |
| Bio databases IDs | |
| Aliases | F-box protein 11 |
| Synonyms | F-box protein 11, FBX11, IDDFBA, JF, LOC103689957, PRMT9, UBR6, UG063H01, VIT1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fbxo11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Right handed beta helix region
- F-box domain superfamily
- protein binding activity, bridging
- Periplasmic copper-binding protein (NosD)
- parallel beta-helix repeat (two copies)
- Protein of unknown function (DUF1565)
- enzyme
- protein binding
- protein-arginine N-methyltransferase
- F-box domain
- ubiquitin-protein transferase activity
- F-box-like
- UBR-box
- Domain present in carbohydrate binding proteins and sugar hydrolses
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- schizophrenia
- obesity
- insulin-dependent diabetes mellitus
- hereditary disorder
- intellectual developmental disorder with dysmorphic facies and behavioral abnormalities
- neurodevelopmental disorder
- mental retardation
- survival
- Alzheimer disease
regulated by
- mir-21 (includes others)
- MAPK6
role in cell
- expression in
- apoptosis
- proliferation
- number
- degradation in
- ubiquitination in
- K48 polyubiquitination in
- pravastatin resistance
- K27 polyubiquitination in
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fbxo11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- protein modification process
- regulation of apoptotic process
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- cytosol
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- protein-arginine N-methyltransferase activity