Tkt Gene Summary [Rat]
Enables cation binding activity; monosaccharide binding activity; and transketolase activity. Involved in pentose-phosphate shunt, non-oxidative branch. Located in endoplasmic reticulum membrane and peroxisome. Orthologous to human TKT (transketolase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tkt |
| Official Name | transketolase [Source:RGD Symbol;Acc:621036] |
| Ensembl ID | ENSRNOG00000016064 |
| Bio databases IDs | |
| Aliases | transketolase |
| Synonyms | HEL107, HEL-S-48, p68, SDDHD, TK, TKT1, TRANSKETOLASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tkt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- vitamin binding
- Transketolase, pyrimidine binding domain
- TPP_enzymes
- calcium ion binding
- enzyme
- protein binding
- magnesium ion binding
- transketolase, bacterial and yeast
- binding protein
- transketolase
- monosaccharide binding
- protein homodimerization
- carbohydrate binding
- Transketolase, C-terminal domain
- thiamine pyrophosphate-dependent enzyme pyrimidine binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- headache
- cancer
- short stature, developmental delay and congenital heart defect
- microphthalmia
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- nonalcoholic steatohepatitis
- hepatitis B virus-related hepatocellular carcinoma
role in cell
- migration
- expression in
- activation in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Nucleus
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- nuclear bodies
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tkt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pentose-phosphate shunt, non-oxidative branch
- pentose-phosphate shunt
- glyceraldehyde-3-phosphate biosynthetic process
- regulation of growth
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- peroxisome
- extracellular vesicular exosome
- nuclear body
- cytosol
- vesicle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- thiamine pyrophosphate binding
- protein binding
- protein homodimerization activity
- transketolase activity
- calcium ion binding