Kirrel1 Gene Summary [Rat]
Predicted to enable cell adhesion molecule binding activity and myosin binding activity. Predicted to be involved in cell-cell adhesion; cell-cell junction maintenance; and glomerular filtration. Predicted to act upstream of or within negative regulation of protein phosphorylation; positive regulation of actin filament polymerization; and renal protein absorption. Located in cell projection membrane; cell-cell junction; and membrane raft. Human ortholog(s) of this gene implicated in nephrotic syndrome type 23. Orthologous to human KIRREL1 (kirre like nephrin family adhesion molecule 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kirrel1 |
| Official Name | kirre like nephrin family adhesion molecule 1 [Source:RGD Symbol;Acc:727883] |
| Ensembl ID | ENSRNOG00000016408 |
| Bio databases IDs | |
| Aliases | kirre like nephrin family adhesion molecule 1 |
| Synonyms | 6720469N11RIK, KIRREL, kirre like nephrin family adhesion molecule 1, NEPH1, NPHS23 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kirrel1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- myosin binding
- Immunoglobulin C1-set domain
- immunoglobulin domain
- Immunoglobulin like
- intracellular domain
- Immunoglobulin I-set domain
- protein binding
- cytosolic tail domain
- PDZ binding motif
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- nephrotic syndrome type 23
- proteinuria
- refractive error
- myopia
role in cell
- expression in
- phosphorylation in
- proliferation
- JQ1 resistance
- survival
- polymerization
- organization
- polarity
- effacement
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- Cytoplasm
- perinuclear region
- cellular membrane
- intercellular junctions
- pedicels
- podocyte filtration slit
- membrane rafts
- cellular protrusions
- dendritic shafts
- podocyte slit diaphragm
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kirrel1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein phosphorylation
- glomerular filtration
- renal protein absorption
- positive regulation of actin filament polymerization
- cell-cell junction maintenance
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- perinuclear region of cytoplasm
- dendritic shaft
- membrane raft
- cell projection membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cell adhesion molecule binding
- myosin binding