Tpmt Gene Summary [Rat]
Predicted to enable S-adenosyl-L-methionine binding activity and thiopurine S-methyltransferase activity. Involved in response to testosterone. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and poor metabolism of thiopurines 1. Orthologous to human TPMT (thiopurine S-methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tpmt |
| Official Name | thiopurine S-methyltransferase [Source:RGD Symbol;Acc:1585162] |
| Ensembl ID | ENSRNOG00000016468 |
| Bio databases IDs | |
| Aliases | thiopurine S-methyltransferase |
| Synonyms | AW106912, LOC681730, OCCLUDIN, thiopurine methyltransferase, thiopurine S-methyltransferase, TPMTD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tpmt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thiopurine S-methyltransferase
- binding protein
- Thiopurine S-methyltransferase (TPMT)
- thiopurine S-methyltransferase, Se/Te detoxification family
- enzyme
- protein binding
- AdoMet_MTases
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neutropenia
- bone marrow toxicity
- myelosuppression
- drug toxicity
- cisplatin-induced hearing loss
- thrombocytosis
- psoriasis
- hearing loss
- hematological toxicity
- inflammatory bowel disease
regulates
- thioguanine nucleotide
- 6-mercaptopurine
- thioguanine
- xenobiotic
- nucleotide
- azathioprine
- azathioprine metabolite
- thioinosinic acid
- thiopurine metabolite
- methylmercaptopurine nucleotide
role in cell
- proliferation
- cell viability
- abnormality
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell-cell contacts
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tpmt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- xenobiotic metabolic process
- xenobiotic catabolic process
- nucleobase-containing compound metabolic process
- methylation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- thiopurine S-methyltransferase activity