Svil Gene Summary [Rat]
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within muscle cell differentiation. Predicted to be located in several cellular components, including costamere; focal adhesion; and sarcolemma. Predicted to be active in actin cytoskeleton and cytoplasm. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Svil |
| Official Name | supervillin [Source:RGD Symbol;Acc:1306354] |
| Ensembl ID | ENSRNOG00000018110 |
| Bio databases IDs | |
| Aliases | supervillin |
| Synonyms | B430302E16Rik, LOC100503917, MFM10, supervillin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Svil often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- Gelsolin repeat
- Villin headpiece domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- myofibrillar myopathy type 10
- fracture of bone
- Rett syndrome
- acute myeloid leukemia
- fibromuscular dysplasia
- vertigo
- infection by Influenza A virus subtype H1N1
role in cell
- cell viability
- cell death
- activation in
- differentiation
- accumulation in
- survival
- binding in
- reorganization
- polarization
- deubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell periphery
- focal adhesions
- podosomes
- actin cytoskeleton
- Nucleus
- costameres
- actin filaments
- midbody
- cytosol
- membrane ruffles
- nucleoplasm
- sarcolemma
- cleavage furrow
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Svil gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- barbed-end actin filament capping
- actin filament severing
- actin polymerization or depolymerization
- skeletal muscle tissue development
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- focal adhesion
- cytoplasm
- cleavage furrow
- actin cytoskeleton
- cytosol
- costamere
- midbody
- cell projection
- plasma membrane
- podosome
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding