Rpl3 Gene Summary [Rat]
Enables 5S rRNA binding activity. Predicted to be involved in translation. Predicted to act upstream of or within cellular response to interleukin-4. Located in ribosome. Part of cytosolic large ribosomal subunit. Is active in synapse. Orthologous to human RPL3 (ribosomal protein L3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Rpl3 |
| Official Name | ribosomal protein L3 [Source:RGD Symbol;Acc:735105] |
| Ensembl ID | ENSRNOG00000016896 |
| Bio databases IDs | |
| Aliases | ribosomal protein L3 |
| Synonyms | ASC-1, F2, J1, L3, ribosomal protein L3, TARBP-B, uL3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rpl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal protein L3
- structural constituent of ribosome
- rpl3p
- 5S rRNA binding
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- acute myeloid leukemia
- T-lymphoblastic leukemia/lymphoma
- leukemia
- Alzheimer disease
- lymphoblastic lymphoma
- accelerated phase chronic myelogenous leukemia
- chronic phase chronic myeloid leukemia
- prostate cancer
- early precursor T-cell acute lymphoblastic leukemia
role in cell
- response by
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- ribosome
- Mitochondria
- cytosol
- nucleoli
- nuclear envelope
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rpl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- cellular response to interleukin-4
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosolic ribosome
- focal adhesion
- cytoplasm
- cytosol
- macromolecular complex
- cytosolic large ribosomal subunit
- nucleolus
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- structural constituent of ribosome