Rps3a Gene Summary [Rat]
Enables mRNA binding activity and translation initiation factor binding activity. Involved in positive regulation of fibroblast proliferation; positive regulation of translation; and response to ethanol. Part of cytosolic small ribosomal subunit. Orthologous to human RPS3A (ribosomal protein S3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps3a |
| Official Name | ribosomal protein S3a [Source:RGD Symbol;Acc:62078] |
| Ensembl ID | ENSRNOG00000011893 |
| Bio databases IDs | |
| Aliases | ribosomal protein S3a |
| Synonyms | 40S ribosomal protein S3a.12/1998, eS1, FTE1, MFTL, ribosomal protein S3A, ribosomal protein S3A1, Rps3a1, S3A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rps3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- mRNA 5' UTR binding
- mRNA binding
- Ribosomal S3Ae family
- protein binding
Pathways
Biological processes and signaling networks where the Rps3a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- diabetes mellitus
- metabolic syndrome X
- recurrent implantation failure
- nonalcoholic steatohepatitis
- nonalcoholic fatty liver disease
regulates
- RNR
- PARP1
role in cell
- cell death
- proliferation
- apoptosis
- quantity
- transformation
- growth
- differentiation
- translation in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- endoplasmic reticulum mitochondria contact site
- pre-ribosome
- cellular membrane
- ribosome
- Nucleus
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rps3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- negative regulation of apoptotic process
- ribosomal small subunit biogenesis
- cell differentiation
- translational initiation
- translation
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- cytosolic ribosome
- cytosolic small ribosomal subunit
- endoplasmic reticulum
- synapse
- nucleolus
- nucleoplasm
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- structural constituent of ribosome
- mRNA 5'-UTR binding