Wdr48 Gene Summary [Rat]
Predicted to enable DNA binding activity; deubiquitinase activator activity; and ubiquitin binding activity. Predicted to be involved in double-strand break repair via homologous recombination; positive regulation of double-strand break repair via homologous recombination; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within several processes, including positive regulation of epithelial cell proliferation; regulation of protein monoubiquitination; and seminiferous tubule development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr48 |
| Official Name | WD repeat domain 48 [Source:RGD Symbol;Acc:1309702] |
| Ensembl ID | ENSRNOG00000016942 |
| Bio databases IDs | |
| Aliases | WD repeat domain 48 |
| Synonyms | 8430408H12Rik, Bun62, KIAA1449, mKIAA1449, P80, RGD1309702, SPG60, UAF1, WD repeat domain 48 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wdr48 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF3337)
- WD domain, G-beta repeat
- coiled-coil domain
- WD40
- protein binding
- protease activator
- DNA binding
- WD-like repeat
- WD40 repeats
- single-stranded DNA binding
- double-stranded DNA binding
- Ubl1_cv_Nsp3_N-like
- SUMO-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metabolic syndrome X
role in cell
- expression in
- proliferation
- apoptosis
- activation in
- survival
- migration
- vesiculation
- invasion by
- ubiquitination in
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- lysosome
- cytosol
- nucleoplasm
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wdr48 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- spermatogenesis
- double-strand break repair via homologous recombination
- embryonic organ development
- response to DNA damage stimulus
- single fertilization
- skeletal system morphogenesis
- skin development
- positive regulation of JAK-STAT cascade
- seminiferous tubule development
- homeostasis of number of cells
- positive regulation of epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- late endosome
- cytosol
- nucleoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- ubiquitin binding
- double-stranded DNA binding
- ubiquitin-specific protease activator activity
- single-stranded DNA binding