Nolc1 Gene Summary [Rat]
Enables several functions, including TFIIB-class transcription factor binding activity; snoRNA binding activity; and snoRNP binding activity. Involved in several processes, including box H/ACA sno(s)RNA metabolic process; positive regulation of DNA-templated transcription; and regulation of protein import into nucleus. Located in nucleolus and nucleoplasm. Part of box C/D methylation guide snoRNP complex and box H/ACA snoRNP complex. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nolc1 |
| Official Name | nucleolar and coiled-body phosphoprotein 1 [Source:RGD Symbol;Acc:621578] |
| Ensembl ID | ENSRNOG00000018704 |
| Bio databases IDs | |
| Aliases | nucleolar and coiled-body phosphoprotein 1 |
| Synonyms | NOPP130, NOPP140, NS5ATP13, Nucleolar and coiled-body phosphoprotein 1, P130, Srp40 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nolc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein repeat
- transcription regulator
- protein kinase inhibitor activity
- protein binding activity, bridging
- snoRNP binding
- snoRNA binding
- transcription factor binding
- protein domain specific binding
- protein binding
- nuclear localization sequence binding
- SRP40, C-terminal domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Nolc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- rheumatoid arthritis
role in cell
- expression in
- apoptosis
- proliferation
- migration
- formation
- translation in
- morphology
- size
- organization
- lengthening
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- nucleolar channel system
- pseudo nucleolar organizer
- fibrillar center
- Cytoplasm
- cell surface
- dense fibrillar component
- nucleoplasm
- nucleoli
- coiled body
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nolc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- neural crest cell development
- nucleolus organization
- rRNA processing
- neural crest formation
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- Cajal body
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- protein binding
- RNA binding
- protein heterodimerization activity
- protein binding, bridging