Mark4 Gene Summary [Rat]
Predicted to enable cytoskeletal anchor activity; protein serine/threonine kinase activity; and tubulin binding activity. Predicted to be involved in several processes, including positive regulation of cellular component biogenesis; positive regulation of protein localization to centrosome; and regulation of centrosome cycle. Predicted to act upstream of or within positive regulation of cell cycle. Predicted to be located in several cellular components, including dendrite; microtubule organizing center; and midbody. Predicted to be part of gamma-tubulin complex. Predicted to be active in cytoplasm and microtubule organizing center. Orthologous to human MARK4 (microtubule affinity regulating kinase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mark4 |
| Official Name | microtubule affinity regulating kinase 4 [Source:RGD Symbol;Acc:1591792] |
| Ensembl ID | ENSRNOG00000017069 |
| Bio databases IDs | |
| Aliases | microtubule affinity regulating kinase 4 |
| Synonyms | 2410090P21Rik, C79806, LOC686800, MAP/microtubule affinity regulating kinase 4, MARKL1, microtubule affinity regulating kinase 4, PAR-1D |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mark4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- cytoskeletal adaptor
- kinase
- Serine/Threonine protein kinases, catalytic domain
- gamma-tubulin binding
- microtubule binding
- Tau-protein kinase
- Protein Kinases, catalytic domain
- AMPKA_C_like
- Kinase associated domain 1
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- glioblastoma
- glioblastoma cancer
- coronary artery disease
- metabolic syndrome X
- glioma formation
- astrocytoma
- oligodendroglioma
- gastroesophageal reflux
role in cell
- expression in
- extension
- phosphorylation in
- binding in
- proliferation
- cell cycle progression
- migration
- loss
- oxygen consumption rate
- association
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- axon-like process
- cilia
- basal bodies
- centrosome
- centriole
- microtubules
- midbody
- microtubule organizing centers
- cytosol
- neurites
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mark4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- microtubule bundle formation
- nervous system development
- positive regulation of programmed cell death
- positive regulation of cell cycle
- microtubule cytoskeleton organization
- positive regulation of NLRP3 inflammasome complex assembly
- positive regulation of flagellum assembly
- protein phosphorylation
- regulation of centrosome cycle
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- microtubule cytoskeleton
- centrosome
- microtubule organizing center
- cilium basal body
- cytoplasm
- cytosol
- gamma-tubulin complex
- midbody
- neuron projection
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- ATP binding
- protein binding
- cytoskeletal adaptor activity
- ubiquitin binding
- tau protein binding
- gamma-tubulin binding
- protein serine/threonine kinase activity
- microtubule binding