Hspa4 Gene Summary [Rat]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of angiogenesis; and regulation of microglial cell activation. Located in lipid droplet. Used to study adult respiratory distress syndrome and middle cerebral artery infarction. Biomarker of Parkinson's disease and liver benign neoplasm. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspa4 |
| Official Name | heat shock protein family A (Hsp70) member 4 [Source:RGD Symbol;Acc:628878] |
| Ensembl ID | ENSRNOG00000016596 |
| Bio databases IDs | |
| Aliases | heat shock protein family A (Hsp70) member 4 |
| Synonyms | AI317151, APG-2, heat shock protein 4, heat shock protein family A (Hsp70) member 4, HEL-S-5a, HS24/P52, Hsp110, Hsp70, Hsp70RY, HSPH2, irp94, mKIAA4025, RY |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hspa4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- transcription factor binding
- protein binding
- Hsp70 protein
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Hspa4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- liver cancer
- epithelial cancer
- infection by Influenza A virus subtype H1N1
- non-insulin-dependent diabetes mellitus
- chronic obstructive pulmonary disease
- pulmonary hypertensive arterial disease
- estrogen receptor positive breast cancer
- metastasis
role in cell
- formation in
- proliferation
- apoptosis
- formation
- expression in
- activation in
- transmembrane potential
- loss
- survival
- oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- cell surface
- Nucleus
- Mitochondria
- lipid droplets
- cytosol
- growth cone
- clastosomes
- mitoplasts
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hspa4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into mitochondrial outer membrane
- chaperone-mediated protein complex assembly
- protein folding
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- adenyl-nucleotide exchange factor activity