Synj2 Gene Summary [Rat]
Enables inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol monophosphate phosphatase activity; and protein domain specific binding activity. Involved in inositol phosphate catabolic process and phosphatidylinositol dephosphorylation. Located in axon terminus; cytoplasmic microtubule; and ruffle membrane. Is active in presynapse. Orthologous to human SYNJ2 (synaptojanin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Synj2 |
| Official Name | synaptojanin 2 [Source:RGD Symbol;Acc:69436] |
| Ensembl ID | ENSRNOG00000017114 |
| Bio databases IDs | |
| Aliases | synaptojanin 2 |
| Synonyms | INPP5H, mKIAA0348, SJ2, Sj2a, Synaptojanin 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Synj2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol 5' phosphatase domain
- RNA recognition motif (RRM) superfamily
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
- inositol-polyphosphate 5-phosphatase
- phosphoinositide 5-phosphatase
- protein binding
- phosphoinositide phosphatase
- proline rich domain
- inositol phosphate binding domain
- SH3-domain binding
- PDZ-domain binding
- phosphatidylinositol-3-phosphatase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- phosphatase
- Domain of unknown function (DUF1866)
- SacI homology domain
Pathways
Biological processes and signaling networks where the Synj2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- hearing loss
- diabetic nephropathy
- age-related hearing loss
- glioblastoma
- glioblastoma cancer
- chronic lymphocytic leukemia
- infection by Dengue virus 2
role in cell
- quantity
- clustering
- organization
- endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic regions
- cellular membrane
- manchette
- Mitochondria
- cytosol
- membrane ruffles
- cytoplasmic microtubule
- axon terminals
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Synj2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- synaptic vesicle endocytosis
- phosphatidylinositol-3-phosphate biosynthetic process
- phosphatidylinositol biosynthetic process
- phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- perinuclear region of cytoplasm
- membrane raft
- cytosol
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
- phosphatidylinositol-3-phosphatase activity
- RNA binding
- protein binding
- phosphatidylinositol phosphate 4-phosphatase activity
- phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
- PDZ domain binding
- SH3 domain binding