Sh3gl2 Gene Summary [Rat]
Enables several functions, including identical protein binding activity; protein kinase binding activity; and transmembrane transporter binding activity. Involved in several processes, including membrane bending; positive regulation of membrane tubulation; and vesicle scission. Located in presynapse. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and synaptic vesicle membrane. Orthologous to human SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3gl2 |
| Official Name | SH3 domain containing GRB2 like 2, endophilin A1 [Source:RGD Symbol;Acc:620276] |
| Ensembl ID | ENSRNOG00000006761 |
| Bio databases IDs | |
| Aliases | SH3 domain containing GRB2 like 2, endophilin A1 |
| Synonyms | 9530001L19Rik, B930049H17RIK, CNSA2, EEN1, EEN-B1, Endophilin 1, Endophilin A1, SH3D2A, SH3 domain containing GRB2 like 2, endophilin A1, SH3-domain GRB2-like 2, SH3P4, SH3PA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sh3gl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- protein kinase binding
- ion channel binding
- coiled-coil domain
- enzyme
- BAR domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Sh3gl2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver metastasis
- Alzheimer disease
- lung metastasis
- Parkinson disease
- breast cancer
- osteoarthropathy
- neurodegeneration
- epithelial cancer
- seizures
- idiopathic femoral head osteonecrosis
role in cell
- cell death
- activation in
- formation
- accumulation in
- production in
- growth
- accumulation
- extension
- vacuolation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- glutaminergic synapse
- endocytic vesicle membrane
- Cytoplasm
- presynaptic regions
- perinuclear region
- postsynaptic region
- cellular membrane
- endocytic tubules
- cytosol
- Golgi membrane
- synaptic vesicles
- nerve ending
- synapse
- early endosomes
- clathrin-coated pits
- filopodia
- perikaryon
- axons
- dendrites
- ribbon synapse
- axosomatic synapses
- exosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sh3gl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- synaptic vesicle uncoating
- central nervous system development
- neuron projection development
- signal transduction
- negative regulation of protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- early endosome
- perinuclear region of cytoplasm
- clathrin-coated endocytic vesicle membrane
- cytoplasm
- cytosol
- Golgi membrane
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- lipid binding