Prl3b1 Gene Summary [Rat]
Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Human ortholog(s) of this gene implicated in carotid artery disease and impulse control disorder. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prl3b1 |
| Official Name | Prolactin family 3, subfamily b, member 1 [Source:RGD Symbol;Acc:2429] |
| Ensembl ID | ENSRNOG00000017185 |
| Bio databases IDs | |
| Aliases | Prolactin family 3, subfamily b, member 1 |
| Synonyms | Csh2, Ghd15, Ghd8, mPL-II, PL, Pl-2, PL-II, prolactin family 3, subfamily B, member 1, RPLII |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prl3b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Somatotropin/prolactin hormone family
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- microsomal fraction
- Cytoplasm