Slc6a3 Gene Summary [Rat]
Enables several functions, including amine binding activity; enzyme binding activity; and sodium:chloride symporter activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; classic dopamine transporter deficiency syndrome; mild cognitive impairment; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc6a3 |
| Official Name | solute carrier family 6 member 3 [Source:RGD Symbol;Acc:3715] |
| Ensembl ID | ENSRNOG00000017302 |
| Bio databases IDs | |
| Aliases | solute carrier family 6 member 3 |
| Synonyms | Amphetamine transporter, DAT, DAT1, DA TRANSPORTER, DAT transporter, Dopamine Transporter, Na-dependent dopamine transporter, PKDYS, PKDYS1, solute carrier family 6 member 3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc6a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dopamine:sodium symporter
- intracellular loop
- PKC phosphorylation site
- protease binding
- Sodium:neurotransmitter symporter family
- protein phosphatase binding
- neurotransmitter transporter
- protein binding
- receptor binding
- noradrenaline:sodium symporter
- monoamine transporter
- binding protein
- serine-rich region
- transmembrane domain
- intracellular domain
- extracellular loop
- Solute carrier families 5 and 6-like; solute binding domain
- transporter
Pathways
Biological processes and signaling networks where the Slc6a3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- non-insulin-dependent diabetes mellitus
- infection
- Alzheimer disease
- weight gain
- weight loss
- obesity
- acute lymphoblastic leukemia
- cancer
- pancreatic cancer
role in cell
- activation in
- expression in
- apoptosis
- activity
- formation
- binding
- cell death
- number
- long-term potentiation
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- basal dendrites
- primary dendrite
- Cytoplasm
- presynaptic regions
- cell surface
- cell borders
- intracellular space
- somatodendritic region
- perinuclear region
- intracellular membranes
- cellular membrane
- endosomes
- lysosome
- Golgi Apparatus
- cytosol
- apical membrane
- presynaptic membrane
- postsynaptic membrane
- plasma membrane projections
- growth cone
- neurites
- nerve ending
- intervaricose axon segments
- synaptosomes
- synapse
- recycling endosomes
- early endosomes
- late endosomes
- membrane rafts
- membrane processes
- filopodia
- perikaryon
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc6a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- norepinephrine transport
- dopamine biosynthetic process
- dopamine transport
- response to cAMP
- lactation
- response to xenobiotic stimulus
- amino acid transport
- positive regulation of multicellular organism growth
- norepinephrine uptake
- neurotransmitter transport
- response to ethanol
- locomotory behavior
- dopamine uptake involved in synaptic transmission
- cognition
- sensory perception of smell
- response to iron ion
- monoamine transport
- prepulse inhibition
- response to cocaine
- adenohypophysis development
- dopamine catabolic process
- response to nicotine
- regulation of dopamine metabolic process
- sodium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- neuronal cell body membrane
- neuronal cell body
- neuron projection
- plasma membrane
- axon terminus
- cell surface
- postsynaptic membrane
- cytoplasm
- membrane
- membrane raft
- axon
- flotillin complex
Molecular Function
What the gene product does at the molecular level
- neurotransmitter transporter activity
- protein binding
- metal ion binding
- amine binding
- dopamine binding
- dopamine:sodium symporter activity
- protease binding
- norepinephrine:sodium symporter activity
- monoamine transmembrane transporter activity
- receptor binding
- protein phosphatase 2A binding