Chrna7 Gene Summary [Rat]
Enables several functions, including acetylcholine binding activity; acetylcholine-gated monoatomic cation-selective channel activity; and enzyme binding activity. Involved in several processes, including neuronal action potential; regulation of ERK1 and ERK2 cascade; and synaptic signaling. Acts upstream of or within regulation of membrane potential. Located in several cellular components, including dendrite; growth cone; and plasma membrane raft. Part of acetylcholine-gated channel complex. Is active in several cellular components, including glycinergic synapse; spine apparatus membrane; and synaptic membrane. Used to study cognitive disorder. Biomarker of rheumatoid arthritis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to several human genes including CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrna7 |
| Official Name | cholinergic receptor nicotinic alpha 7 subunit [Source:RGD Symbol;Acc:2348] |
| Ensembl ID | ENSRNOG00000010853 |
| Bio databases IDs | |
| Aliases | cholinergic receptor nicotinic alpha 7 subunit |
| Synonyms | AC254952.1, AChR α 7, AChR α 7 Receptor, Alpha 7 nAChR, alpha7 NICOTINIC ACETYLCHOLINE receptor, Alpha7 nicr, BTX, cholinergic receptor, nicotinic, alpha 7 (neuronal), cholinergic receptor nicotinic alpha 7 subunit, cholinergic receptor, nicotinic, α 7 (neuronal), cholinergic receptor nicotinic α 7 subunit, NACHRA7, NACHR alpha7, NARAD, α-7nAChR, α 7 nicotinic acetylcholine receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chrna7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- ion channel
- acetylcholine receptor
- G protein-binding cluster
- Neurotransmitter-gated ion-channel transmembrane region
- intracellular domain
- tail domain
- acetylcholine binding
- transmembrane receptor
- extracellular domain
- intracellular loop
- protein kinase binding
- calcium channel
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- beta-amyloid binding
- chloride channel regulator
- ATPase binding
- neurotransmitter receptor
- LGIC_ECD
- adenylate cyclase binding
- cytoplasmic loop
- Neurotransmitter-gated ion-channel ligand binding domain
- transmembrane domain
- ligand-gated ion channel
- protein homodimerization
- cation channel
- toxin binding
Pathways
Biological processes and signaling networks where the Chrna7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pulmonary hypertension
- tobacco-related disorder
- dry eye
- acute respiratory distress syndrome
- acute myeloid leukemia
- COVID-19
- psychological disorder
- alcoholism
- schizoaffective disorder
- community acquired pneumonia
role in cell
- production in
- proliferation
- expression in
- phosphorylation in
- activation in
- cell viability
- cell death
- transmembrane potential
- growth
- neuroprotection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- postsynaptic region
- cellular membrane
- endoplasmic reticulum membrane
- plasma membrane extracellular face
- apical membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- axonal membrane
- growth cone
- synaptosomes
- synapse
- membrane rafts
- perikaryon
- axons
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chrna7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- positive regulation of long-term synaptic potentiation
- positive regulation of cell proliferation
- memory
- positive regulation of angiogenesis
- learning or memory
- positive regulation of protein metabolic process
- ion transport
- sensory processing
- response to hypoxia
- cognition
- calcium ion transport
- calcium ion transmembrane transport
- negative regulation of tumor necrosis factor production
- regulation of excitatory postsynaptic membrane potential
- signal transduction
- synapse organization
- ion transmembrane transport
- synaptic transmission
- dendritic spine organization
- response to nicotine
- positive regulation of MAPK cascade
- cellular calcium ion homeostasis
- short-term memory
- regulation of membrane potential
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of excitatory postsynaptic membrane potential
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- membrane
- synapse
- acetylcholine-gated channel complex
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- toxin binding
- chloride channel regulator activity
- ion channel activity
- protein binding
- acetylcholine receptor activity
- protein homodimerization activity
- calcium channel activity
- acetylcholine-gated cation channel activity
- acetylcholine binding
- beta-amyloid binding