Hs3st2 Gene Summary [Rat]
Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase activity. Involved in circadian rhythm. Predicted to be located in Golgi membrane. Human ortholog(s) of this gene implicated in colon cancer; lung cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hs3st2 |
| Official Name | heparan sulfate-glucosamine 3-sulfotransferase 2 [Source:RGD Symbol;Acc:727787] |
| Ensembl ID | ENSRNOG00000017659 |
| Bio databases IDs | |
| Aliases | heparan sulfate-glucosamine 3-sulfotransferase 2 |
| Synonyms | 30ST2, 3OST2, 6430516N12RIK, A830061E14, A830061E14Rik, h3-OST-2, heparan sulfate (glucosamine) 3-O-sulfotransferase 2, heparan sulfate-glucosamine 3-sulfotransferase 2, heparan sulphate (glucosamine) 3-O-sulphotransferase 2, heparan sulphate-glucosamine 3-sulphotransferase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hs3st2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- [heparan sulfate]-glucosamine 3-sulfotransferase 1
- Sulfotransferase domain
- [heparan sulfate]-glucosamine 3-sulfotransferase 2
- enzyme
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the Hs3st2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hs3st2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process, enzymatic modification
- glycosaminoglycan biosynthetic process
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
- sulfotransferase activity
- [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity