Hs3st2 Gene Summary [Mouse]

Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and skeleton. Human ortholog(s) of this gene implicated in colon cancer; lung cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Hs3st2
Official Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 2 [Source:MGI Symbol;Acc:MGI:1333802]
Ensembl ID
ENSMUSG00000046321
Bio databases IDs NCBI: 195646 Ensembl: ENSMUSG00000046321
Aliases heparan sulfate (glucosamine) 3-O-sulfotransferase 2
Synonyms 30ST2, 3OST2, 6430516N12RIK, A830061E14, A830061E14Rik, h3-OST-2, heparan sulfate (glucosamine) 3-O-sulfotransferase 2, heparan sulfate-glucosamine 3-sulfotransferase 2, heparan sulphate (glucosamine) 3-O-sulphotransferase 2, heparan sulphate-glucosamine 3-sulphotransferase 2
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hs3st2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • sulfotransferase
  • [heparan sulfate]-glucosamine 3-sulfotransferase 1
  • Sulfotransferase domain
  • [heparan sulfate]-glucosamine 3-sulfotransferase 2
  • enzyme
  • Sulfotransferase family

Pathways

Biological processes and signaling networks where the Hs3st2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • chronic obstructive pulmonary disease
  • androgenic alopecia
  • epileptic seizure
regulated by
  • isoproterenol
  • decitabine
  • IL1B
  • EGR3
  • propranolol
  • bucladesine
  • TCF4
  • norepinephrine
regulates
  • glycosaminoglycan
  • heparan sulfate proteoglycan

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • pH resistant lipid raft fraction
  • detergent resistant lipid raft fraction
  • cellular membrane
  • Golgi membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Hs3st2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • heparan sulfate proteoglycan biosynthetic process, enzymatic modification
  • glycosaminoglycan biosynthetic process

Cellular Component

Where in the cell the gene product is active
  • membrane
  • Golgi membrane

Molecular Function

What the gene product does at the molecular level
  • [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
  • sulfotransferase activity
  • [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.