Brsk1 Gene Summary [Rat]
Enables protein serine/threonine kinase activity. Involved in neurotransmitter secretion and regulation of synaptic vesicle priming. Located in distal axon. Is active in cholinergic synapse; postsynaptic density; and synaptic vesicle. Orthologous to human BRSK1 (BR serine/threonine kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brsk1 |
| Official Name | BR serine/threonine kinase 1 [Source:RGD Symbol;Acc:1563268] |
| Ensembl ID | ENSRNOG00000017673 |
| Bio databases IDs | |
| Aliases | BR serine/threonine kinase 1 |
| Synonyms | BR serine/threonine kinase 1, Gm1100, hSAD1, KIAA1811, MGC99905, RGD1563268, SAD-B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Brsk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- gamma-tubulin binding
- Tau-protein kinase
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- bradykinesia
role in cell
- differentiation
- DNA damage response
- priming
- clustering
- abnormal morphology
- G2/M phase transition
- development
- plasticity
- G2/M phase
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- Nucleus
- centrosome
- nucleoplasm
- synaptic vesicles
- synapse
- chromatin
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Brsk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- neuron differentiation
- microtubule cytoskeleton organization involved in establishment of planar polarity
- response to UV
- response to DNA damage stimulus
- protein phosphorylation
- associative learning
- neurotransmitter secretion
- G2/M transition of mitotic cell cycle
- regulation of synaptic vesicle clustering
- centrosome duplication
- regulation of axonogenesis
- axonogenesis
- regulation of synaptic plasticity
- establishment of cell polarity
- regulation of neuron projection development
- peptidyl-serine phosphorylation
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- presynaptic active zone
- cytoplasm
- synaptic vesicle
- cell junction
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- tau-protein kinase activity
- protein kinase binding
- ATP binding
- tau protein binding
- gamma-tubulin binding
- protein serine/threonine kinase activity