Shc1 Gene Summary [Rat]
Enables enzyme binding activity; epidermal growth factor receptor binding activity; and phosphotyrosine residue binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to phorbol 13-acetate 12-myristate; and insulin receptor signaling pathway. Located in endosome membrane. Part of Shc-EGFR complex. Used to study glomerulosclerosis. Biomarker of familial hyperlipidemia and hepatocellular carcinoma. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shc1 |
| Official Name | SHC adaptor protein 1 [Source:RGD Symbol;Acc:620446] |
| Ensembl ID | ENSRNOG00000020657 |
| Bio databases IDs | |
| Aliases | SHC adaptor protein 1 |
| Synonyms | p52SHC, p66, P66shc, SHC, Shc (46 kDa isoform), SHCA, SHC adaptor protein 1, Shc p66 isoform, src homology 2 domain-containing transforming protein C1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Shc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- insulin receptor binding
- phosphoprotein binding
- ephrin receptor binding
- identical protein binding
- insulin-like growth factor receptor binding
- proline rich domain
- Grb2 binding domain
- docking domain
- receptor tyrosine kinase binding
- Src homology 2 (SH2) domain
- transmembrane receptor protein tyrosine kinase adaptor protein
- growth factor binding
- phospholipid binding
- hormone binding
- epidermal growth factor receptor binding
- protein phosphatase binding
- CH1 domain
- phosphotyrosine binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- collagen homology domain
- neurotrophin TRKA receptor binding
- phosphotyrosine motif
- phosphorylation site
- CH2 domain (from immunoglobulin)
- binding protein
- cysteine-histidine rich domain
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Shc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- EIF2 Signaling
- ErbB2-ErbB3 Signaling
- ErbB4 Signaling
- G Beta Gamma Signaling
- GDNF Family Ligand-Receptor Interactions
- Glioma Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- IGF-1 Signaling
- IL-2 Signaling
- IL-6 Signaling
- IL-7 Signaling Pathway
- JAK/Stat Signaling
- Melanocyte Development and Pigmentation Signaling
- Neuregulin Signaling
- Oncostatin M Signaling
- PAK Signaling
- PPAR Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Thyroid Cancer Signaling
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- squamous cell cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- hypoplasia
- liver cancer
- digestive system cancer
- prostate cancer
- colorectal neoplasm
role in cell
- expression in
- production in
- proliferation
- apoptosis
- cell death
- phosphorylation in
- activation in
- differentiation
- molecular cleavage in
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- mitochondrial fraction
- perinuclear region
- cellular tail
- inner membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- caveolar membranes
- endosomal membrane
- actin stress fibers
- perikaryon
- clathrin-coated vesicles
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Shc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
- epidermal growth factor receptor signaling pathway
- positive regulation of cell proliferation
- insulin-like growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- defense response to bacterium
- heart development
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- angiogenesis
- cellular response to growth factor stimulus
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- actin cytoskeleton organization
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- mitochondrial matrix
- cytosol
- Shc-EGFR complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- epidermal growth factor receptor binding
- ephrin receptor binding
- transmembrane receptor protein tyrosine kinase adaptor activity
- insulin receptor binding
- phospholipid binding
- epidermal growth factor binding
- neurotrophin TRKA receptor binding
- receptor tyrosine kinase binding
- insulin-like growth factor receptor binding