Ucp3 Gene Summary [Rat]
Predicted to enable oxidative phosphorylation uncoupler activity and proton transmembrane transporter activity. Involved in several processes, including response to fenofibrate; response to insulin; and response to superoxide. Predicted to be located in mitochondrial inner membrane. Used to study type 2 diabetes mellitus. Biomarker of congestive heart failure; hypertension; hyperthyroidism; hypothyroidism; and prediabetes syndrome. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ucp3 |
| Official Name | uncoupling protein 3 [Source:RGD Symbol;Acc:3933] |
| Ensembl ID | ENSRNOG00000017716 |
| Bio databases IDs | |
| Aliases | uncoupling protein 3 |
| Synonyms | SLC25A9, uncoupling protein 3, uncoupling protein 3 (mitochondrial, proton carrier) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ucp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- Mitochondrial carrier protein
- protein binding
- transporter
- oxidative phosphorylation uncoupler
Pathways
Biological processes and signaling networks where the Ucp3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- androgenic alopecia
- Duchenne muscular dystrophy
- obesity
- non-insulin-dependent diabetes mellitus
- insulin resistance
- hyperphagia
- severe obesity and type II diabetes
- morbid obesity
- dyslipidemia
role in cell
- expression in
- production in
- oxidative stress response
- transmembrane potential
- growth
- activity
- function
- respiration
- thermogenesis in
- respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ucp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cold
- response to hypoxia
- response to insulin stimulus
- response to glucocorticoid stimulus
- lipid metabolic process
- response to nutrient
- cellular response to hormone stimulus
- response to activity
- respiratory gaseous exchange
- response to superoxide
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen ion transmembrane transporter activity
- oxidative phosphorylation uncoupler activity
- calcium ion transmembrane transporter activity