Pdia3

Enables MHC class I protein binding activity; peptidase activity; and protein-disulfide reductase (glutathione) activity. Involved in several processes, including cellular response to nonylphenol; response to benzene; and response to ischemia. Located in several cellular components, including acrosomal vesicle; apical plasma membrane; and smooth endoplasmic reticulum. Part of TAP complex. Used to study autoimmune hepatitis and irritable bowel syndrome. Biomarker of asphyxia neonatorum; irritable bowel syndrome; liver cirrhosis; post-traumatic stress disorder; and pulmonary hypertension. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdia3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Pdia3 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Pdia3 gene, providing context for its role in the cell.