Septin1 Gene Summary [Rat]
Predicted to enable GTPase activity; identical protein binding activity; and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis; protein localization; and regulation of exocytosis. Predicted to act upstream of or within meiotic metaphase chromosome alignment and spindle assembly involved in female meiosis. Predicted to be located in meiotic spindle and midbody. Predicted to be part of septin complex. Predicted to be active in cell division site; cytoskeleton; and synaptic vesicle. Orthologous to human SEPTIN1 (septin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Septin1 |
| Official Name | septin 1 [Source:RGD Symbol;Acc:1307216] |
| Ensembl ID | ENSRNOG00000017804 |
| Bio databases IDs | |
| Aliases | septin 1 |
| Synonyms | DIFF6, LARP, PNUTL3, SEP1, SEPT1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Septin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dGTPase
- ribosome biogenesis GTP-binding protein YsxC/EngB
- enzyme
- protein binding
- identical protein binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Septin1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- midbody
- meiotic spindles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Septin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic metaphase plate congression
- protein localization
- spindle assembly involved in female meiosis
- regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- centrosome
- cell division site
- synaptic vesicle
- midbody
- meiotic spindle
- septin complex
- septin ring
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- GTPase activity
- binding, bridging