Septin7 Gene Summary [Rat]
A structural constituent of postsynapse. Involved in postsynapse organization. Is active in glutamatergic synapse and postsynaptic septin cytoskeleton. Orthologous to human SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Septin7 |
| Official Name | septin 7 [Source:RGD Symbol;Acc:620469] |
| Ensembl ID | ENSRNOG00000006545 |
| Bio databases IDs | |
| Aliases | septin 7 |
| Synonyms | CDC10, CDC3, E430034N22, NBLA02942, Sep7, SEPT7, SEPT7A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Septin7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- GTPase domain
- 50S ribosome-binding GTPase
- coiled-coil domain
- protein binding
- structural molecule
- identical protein binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Septin7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- non-small cell lung carcinoma
- non-small cell lung cancer
- open-angle glaucoma
role in cell
- morphogenesis
- migration
- morphology
- stability
- elongation
- assembly
- stabilization
- organization
- binding in
- binucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- glutaminergic synapse
- sperm annulus
- non-motile cilium
- cytoskeleton
- cellular membrane
- focal complexes
- cell cortex
- Nucleus
- Plasma Membrane
- vesicles
- axonemes
- actin filaments
- midbody
- cytoplasmic bridges
- septin ring
- cytosol
- apical membrane
- presynaptic membrane
- nuclear foci
- neurites
- synaptosomes
- synapse
- actin stress fibers
- cleavage furrow
- perikaryon
- axon terminals
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Septin7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- spermatogenesis
- cell differentiation
- protein localization
- regulation of embryonic cell shape
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cell division site
- cleavage furrow
- kinetochore
- axoneme
- septin ring
- nucleus
- extracellular vesicular exosome
- sperm annulus
- stress fiber
- spindle
- cytosol
- midbody
- septin complex
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- cadherin binding
- GTPase activity
- structural molecule activity
- binding, bridging